Saat otot jantung rusak, maka troponin akan dilepaskan ke peredarah darah. Bila kerusakan jantung meningkat, maka jumlah troponin yang dilepaskan juga semakin banyak.
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Dalam kondisi regular, troponin hanya terdapat di dalam sel otot dan tidak ditemukan dalam peredaran darah. Namun apabila sel otot mengalami kerusakan, troponin akan dilepaskan ke dalam darah. Semakin tinggi kadar troponin, maka hal itu juga mengindikasikan kerusakan sel otot yang semakin parah.
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